The management of androgenetic alopecia poses challenges due to its chronic nature, the requirement for continuous treatment, and the potential adverse effects associated with therapies. To address these concerns and optimize treatment outcomes, authors Venkatram Mysore, Muthuvel Kumaresan, Shuken Dashore, and Aniketh Venkatram propose a scheme that incorporates combination treatments with a rotational approach. This strategy takes into account the current evidence regarding efficacy, pharmacokinetic properties, long-term convenience of administration, side effect profile, and patient acceptance. By utilizing this scheme, they aim to enhance treatment efficacy, minimize side effects, and ensure patient compliance in managing androgenetic alopecia.
Combinational and rotational therapy involves using different drugs and procedures at different periods to achieve optimal treatment outcomes while minimizing side effects and preventing resistance. This approach has been widely used in dermatology, cancer treatment, and chronic conditions. In the case of androgenetic alopecia (AGA), a chronic cosmetic disease that affects younger patients, rotational therapy can address their specific needs and concerns. It helps improve long-term compliance, provides clarity for healthcare practitioners, and navigates the influx of new treatments with limited evidence. This paper explores how existing AGA treatment modalities can be adapted for rotational therapy.
This paper also explores the various modalities that can be incorporated into combinational and rotational approaches for the treatment of androgenetic alopecia (AGA). These modalities include minoxidil, finasteride, hair transplantation, platelet-rich plasma (PRP), low-level laser therapy (LLLT), vitamins, peptides, diet, and lifestyle modifications. The paper emphasizes the importance of understanding the pathophysiology, mechanisms of action, pharmacokinetics, and side effect profiles of each treatment. It discusses how these modalities can be used together or rotated at intervals based on current knowledge of AGA’s course, pathogenesis, and treatment durations.
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